This condition is typically caused by two factors. It may be a result of processes that raise production of ammonia. Hyperammonemia, resulting from decreased ammonia elimination, can occur due to medicinal side effects as well as the onset of conditions like:
- Fulminant hepatic failure
- Portosystemic shunting
Hyperammonemia may also arise due to processes that reduce elimination of ammonia. Some conditions increasing ammonia production are:
It enhances ammonia levels in the bloodstream and may be accompanied by GI hemorrhage, trauma, total parenteral nutrition (TPN), and steroid use.
Some drugs disrupt the urea cycle and give rise to Hyperammonemia. These include Glycine, a medicine that is used at the time of transurethral resection of the prostate. Glycine stimulates production of ammonia in humans.