What Is the Prognosis of Rosai-Dorfman Disease?

Q:
What is the prognosis of Rosai-Dorfman disease?

A:
Rosai-Dorfman disease (RDD) is a rare, benign condition. It involves overproduction and accumulation of histiocytes (a type of white cell) in the lymph nodes. Mostly, it affects the lymph nodes in the neck.

Generally, this disease follows a benign self-limiting course. In other words, the prognosis of this disease is good, since this condition can resolve on its own within months or a few years.

However, when it comes with severe complications and impacts the digestive tract (mostly the liver and pancreas), the prognosis may be guarded.

Fortunately, most patients can make a complete recovery with appropriate treatment, which includes:

  • surgical removal of histiocytic lesions,
  • and therapy with certain drugs, including steroids, alpha-interferon, and anticancer drugs.

Keywords: Rosai-Dorfman disease prognosis; RDD prognosis.

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