What is kyrle’s disease?
Kyrle’s disease is a rare disease, defined as a form of an acquired perforating disease. It affects both men and women with 1:6 ratio, and it most affects people aged 30 to 50.
Kyrle’s disease is characterized by large papules with central keratin plus the skin, appearing mostly on the legs and are often in conjunction with hepatic, renal or diabetic disorders. Other symptoms may be presented as follows:
- Diabetes mellitus
- Hepatic insufficiency
- Excess sugar in the urine
- Presence of albumin in the urine
- Hyperkeratotic cone-shaped papular plugs
- Hyperkeratotic verrucous plaques
The exact cause of Kyrle’s disease is unclear and sometimes can be idiopathic, but it may be related to underlying disorders such as diabetes mellitus, chronic renal failure, hyperlipoproteinemia, hepatic abnormalities, congestive heart failure, etc.
Keywords: kyrle’s disease definition; causes kyrle’s disease; kyrle’s disease symptoms.