What Are the Differences between Dermatomyositis and Lupus?

What are the differences between dermatomyositis and lupus?

Dermatomyositis and lupus are not strange to many patients because they both have red pimples on the skin surface of patients. And these pimples are so similar that it is difficult to tell dermatomyositis from lupus.

However, dermatomyositis and lupus are actually different in causes, symptoms and treatments.

Difference in causes

  •  ŸDermatomyositis is an inflammatory lesion that occurs in the striated muscle and is mainly infiltrated by lymphocytes. It is generally believed that the occurrence of dermatomyositis is related to genetic and viral infections.
  • However, the cause of lupus erythematosus is not fully understood. The pathogenic factors causing lupus erythematosus are currently considered to include genetic factors, sex hormones, ultraviolet radiation, drugs and the like.

Difference in symptoms

  • Patients with dermatomyositis may develop severe muscle weakness, rhabdomyolysis, myosinuria, and renal failure. And some may have symptoms such as morning stiffness, fatigue, loss of appetite, weight loss, fever and joint pain.
  • Lupus erythematosus is divided into discoid lupus erythematosus and systemic lupus erythematosus.
  • In the early stage of discoid lupus erythematosus, there will be one or several bright red spots on the surface of the patient’s skin.
  • Patients with systemic lupus erythematosus have multiple systemic manifestations at onset, and the symptoms are complex.

Difference in treatments

  • Ÿ Dermatomyositis can be treated by taking an immunosuppressive agent.
  • Ÿ Lupus erythematosus have complex symptoms, so the treatment is complicated. At present, it is mainly treated by oral hydroxychloroquine and topical glucocorticosteroid ointment.

Both dermatomyositis and lupus are harmful to the human body, so it is necessary to have timely treatment if you have unfortunately suffered from dermatomyositis or lupus.


Keywords: dermatomyositis lupus; lupus dermatomyositis.

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