TPA Contraindications for Stroke

TPA or IV rtPA, short for tissue plasminogen activator, is a drug that helps dissolve the clot of blood. It’s the only FDA approved treatment for ischemic strokes.

However, there are some conditions in which tPA treatment must be stopped.

Absolute Contraindications:

  • Abnormal blood glucose (<50 mg/dL).
  • Active internal bleeding.
  • Endocarditis, suspected or confirmed.
  • Head trauma in past 3 months.
  • Intracranial hemorrhage, recent or past.
  • Known intracranial arteriovenous malformation, neoplasm, or aneurysm.
  • Known bleeding diathesis.
  • Neurosurgery in past 3 months.
  • Stroke in past 3 months.
  • Subarachnoid hemorrhage.
  • Uncontrolled hypertension (>185 mmHg SBP, or >110 mmHg DBP).


Keywords: TPA contraindications for stroke.

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