TPA or IV rtPA, short for tissue plasminogen activator, is a drug that helps dissolve the clot of blood. It’s the only FDA approved treatment for ischemic strokes.
However, there are some conditions in which tPA treatment must be stopped.
- Abnormal blood glucose (<50 mg/dL).
- Active internal bleeding.
- Endocarditis, suspected or confirmed.
- Head trauma in past 3 months.
- Intracranial hemorrhage, recent or past.
- Known intracranial arteriovenous malformation, neoplasm, or aneurysm.
- Known bleeding diathesis.
- Neurosurgery in past 3 months.
- Stroke in past 3 months.
- Subarachnoid hemorrhage.
- Uncontrolled hypertension (>185 mmHg SBP, or >110 mmHg DBP).
Keywords: TPA contraindications for stroke.