Researchers analyzed data on nearly 16,000 people with sleep apnea and more than 63,000 people without apnea who were followed for a median of nearly six years. (Half were followed longer, half for less time.)
Of course, the study couldn’t prove that apnea causes gout, just that there was an association.
The study was published Aug. 30 in the journal Arthritis & Rheumatology.
“People with sleep apnea are at an increased risk of gout in both the short and long term. Since this risk was highest in people with normal body mass index, doctors and other health professionals should consider the possibility of gout in patients with sleep apnea regardless of body mass index,” study co-leader Edward Roddy said in a journal news release.
Roddy is a clinical lecturer in rheumatology at Keele University in Staffordshire, England.
It’s believed that periodic low levels of oxygen caused by sleep apnea lead to overproduction of uric acid, causing gout, the researchers said.
“Sleep apnea is commonly treated with continuous positive airways pressure — or CPAP — therapy. Since CPAP treatment corrects low oxygen levels it might also be expected to reduce uric acid levels, which could possibly reduce the risk of developing gout or treat existing gout,” said study co-leader Milica Blagojevic-Bucknall.
She said more research is needed to investigate the effect of CPAP treatment in people with gout.
Blagojevic-Bucknall is a lecturer at Keele University.