Non-Caseating vs Caseating Granuloma

vs Caseating Granuloma

Granuloma is a form of chronic inflammation that helps your body to contain the spread of an infectious agent. Based on its pathogenesis, granuloma can be divided into immune granuloma and foreign body granuloma.

What’s non-caseating and caseating granuloma?

If the central zone of the granuloma undergoes necrosis because of hypoxia and free radical activity, this granuloma can be called caseating granuloma. Otherwise, it’s a non-caseating granuloma. In a word, the key difference between caseating and non-caseating granuloma is whether there is a whitish, cheese like debris at the center.


Formation of a granuloma due to an intrinsic or extrinsic injurious agent happens in both two cases.


Besides their key difference, the diseases in which non-caseating and caseating granuloma happen are distinct. Caseating granuloma typically occurs in tuberculosis, while non-caseating one primarily occurs in conditions such as sarcoidosis, Crohn’s disease, and leprosy.

If you have questions, please consult your doctor.

Keywords: non-caseating; caseating granuloma; inflammation

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