Naproxen: Uses & Side Effects

Naproxen is a nonsteroidal
anti-inflammatory drug (NSAID). It works by reducing hormones that cause
inflammation and pain in the body.

Naproxen is used to treat pain or
inflammation caused by conditions such as arthritis, ankylosing spondylitis,
tendinitis, bursitis, gout, or menstrual cramps. It can also be used to treat
acute pain caused by other conditions not listed in this medication guide.

The delayed-release or extended-release
tablets are slower-acting forms of naproxen that are used only for treating
chronic conditions such as arthritis or ankylosing spondylitis. These forms
will not work fast enough to treat acute pain.

should I take naproxen?

Use naproxen exactly as directed on the
label, or as prescribed by your doctor. Do not take this medicine in larger
amounts or for longer than recommended. Use the lowest dose that is effective
in treating your condition.

Do not crush, chew, or break a naproxen
tablet. Swallow it whole.

Shake the oral suspension (liquid) well
just before you measure a dose. Measure liquid medicine with the dosing syringe
provided, or with a special dose-measuring spoon or medicine cup. If you do not
have a dose-measuring device, ask your pharmacist for one.

If you change brands, strengths, or forms
of this medicine, your dosage needs may change. Ask your pharmacist if you have
any questions about the kind of naproxen you are using.

If a child is using this medicine, tell
your doctor if the child has any changes in weight. Doses are based on weight
in children, and any changes may affect your child’s dose.

If you use this medicine long-term, you may
need frequent medical tests.

This medicine can cause unusual results
with certain medical tests. Tell any doctor who treats you that you are using

Store at room temperature away from
moisture, heat, and light. Keep the bottle tightly closed when not in use.

Read all patient information, medication
guides, and instruction sheets provided to you. Ask your doctor or pharmacist
if you have any questions.


Naproxen may also cause stomach or
intestinal bleeding, which can be fatal. These conditions can occur without
warning while you are using this medicine, especially in older adults.

You should not use naproxen if you are
allergic to it, or if you have ever had an asthma attack or severe allergic
reaction after taking aspirin or an NSAID.

Ask a doctor or pharmacist if it is safe
for you to use this medicine if you have:

  • heart disease, high blood pressure, high cholesterol, diabetes, or
    if you smoke;
  • a history of heart attack, stroke, or blood clot;
  • a history of stomach ulcers or bleeding;
  • asthma;
  • liver or kidney disease;
  • fluid retention.

Taking naproxen during the last 3 months of
pregnancy may harm the unborn baby. Ask a doctor before using this medicine if
you are pregnant. It may interfere with ovulation, causing temporary

Naproxen can pass into breast milk and may
cause side effects in the nursing baby. You should not breast-feed while using
this medicine.

Naproxen is not approved for use by anyone
younger than 2 years old. Do not give this medicine to a child without medical


Get emergency medical help if you have
signs of an allergic reaction to naproxen: wheezing or trouble breathing;
hives; swelling of your face, lips, tongue, or throat.

Get emergency medical help if you have
signs of a heart attack or stroke: chest pain spreading to your jaw or
shoulder, sudden numbness or weakness on one side of the body, slurred speech,
feeling short of breath.

Stop using naproxen and call your doctor at
once if you have:

  • shortness of breath (even with mild exertion);
  • swelling or rapid weight gain;
  • the first sign of any skin rash, no matter how mild;
  • signs of stomach bleeding – bloody or tarry stools, coughing up
    blood or vomit that looks like coffee grounds;
  • liver problems – nausea, upper stomach pain, itching, tired feeling,
    flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice
    (yellowing of the skin or eyes);
  • kidney problems – little or no urinating, painful or difficult
    urination, swelling in your feet or ankles, feeling tired or short of breath;
  • low red blood cells (anemia) – pale skin, feeling light-headed or
    short of breath, rapid heart rate, trouble concentrating;
  • severe skin reaction – fever, sore throat, swelling in your face or
    tongue, burning in your eyes, skin pain followed by a red or purple skin rash
    that spreads (especially in the face or upper body) and causes blistering and

Common naproxen side effects may include:

  • indigestion, heartburn, stomach pain, nausea;
  • headache, dizziness, drowsiness;
  • bruising, itching, rash;
  • swelling;
  • ringing in your ears.


Ask your doctor before using naproxen if
you take an antidepressant such as citalopram, escitalopram, fluoxetine
(Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or
vilazodone. Taking any of these medicines with an NSAID may cause you to bruise
or bleed easily.

Ask a doctor or pharmacist if it is safe for
you to use this medicine if you are also using any of the following drugs:

  • cholestyramine;
  • cyclosporine;
  • digoxin;
  • lithium;
  • methotrexate;
  • pemetrexed;
  • phenytoin or similar seizure medications;
  • probenecid;
  • warfarin (Coumadin, Jantoven) or similar blood thinners;
  • a diuretic or “water pill”;
  • heart or blood pressure medication;
  • insulin or oral diabetes medicine.

Always consult your healthcare provider to
ensure the information displayed on this page applies to your personal

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