Larotrectinib: Uses & Sides Effects

Larotrectinib is used to treat certain
tumors that are caused by an abnormal “NTRK” gene. Larotrectinib is
used when the cancer has spread to other parts of the body or cannot be removed
with surgery or other cancer treatments.

Larotrectinib is sometimes given after
other cancer treatments did not work or have stopped working.

Larotrectinib was approved by the US Food
and Drug Administration (FDA) on an “accelerated” basis. In clinical
studies, some people responded to larotrectinib, but further studies are
needed.

How
should I take larotrectinib?

Your doctor will perform a test to make
sure larotrectinib is the right treatment for your type of tumor.

Follow all directions on your prescription
label and read all medication guides or instruction sheets. Your doctor may
occasionally change your dose. Use the medicine exactly as directed.

Take this medicine with a full glass of
water.

You may take larotrectinib with or without food.

Swallow the capsule whole and do not crush,
chew, break, or open it.

Measure liquid medicine carefully. Use the
dosing syringe provided, or use a medicine dose-measuring device (not a kitchen
spoon).

Read and carefully follow any Instructions
for Use provided with your medicine. Ask your doctor or pharmacist if you do
not understand these instructions.

You will need frequent medical tests to
check your liver function.

Your doctor will determine how long to
treat you with larotrectinib.

If you vomit shortly after taking
larotrectinib, do not take another dose. Wait until your next scheduled dose
time to take the medicine again.

Store the capsules at room temperature,
away from moisture and heat.

Store the liquid medicine in the
refrigerator, do not freeze. Throw away any unused liquid after 90 days.

Precautions

Tell your doctor if you have ever had:

  • liver disease;
  • nerve problems.

You may need to have a negative pregnancy
test before starting this treatment.

Both men and women using larotrectinib
should use effective birth control to prevent pregnancy. Larotrectinib can harm
an unborn baby or cause birth defects if the mother or father is using this
medicine. Keep using birth control for at least 1 week after your last dose.

This medicine may affect fertility (ability
to have children) in women. However, it is important to use birth control to
prevent pregnancy because larotrectinib can harm an unborn baby.

Do not breast-feed while using this
medicine, and for at least 1 week after your last dose.

Side
Effects

Get emergency medical help if you have
signs of an allergic reaction: hives; difficult breathing; swelling of your
face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe or ongoing stomach pain, vomiting, or diarrhea;
  • confusion, memory problems, severe dizziness;
  • problems with speech or coordination;
  • numbness, tingling, or burning pain in your hands or feet;
  • fever, flu symptoms, sore throat, cough;
  • sores or ulcers in your mouth or on your skin;
  • unusual tiredness, feeling light-headed or short of breath;
  • pale skin, cold hands and feet;
  • pain, warmth, redness, or swelling under your skin;
  • liver problems–loss of appetite, stomach pain (upper right side),
    nausea, vomiting, dark urine, clay-colored stools, jaundice (yellowing of the
    skin or eyes).

Your cancer treatments may be delayed or
permanently discontinued if you have certain side effects.

Common side effects may include:

  • nausea, vomiting, diarrhea, constipation;
  • cough;
  • dizziness;
  • tiredness;
  • abnormal liver function tests.

Always consult your healthcare provider to
ensure the information displayed on this page applies to your personal
circumstances.

Keyword: larotrectinib.

Leave a Reply