Is Progeria Passed Down From Parents to Child?

Q:
Is progeria passed down from parents to child?

A:
Progeria
is not usually passed down in families.

The gene change is almost always a chance occurrence that is extremely rare. Children with other types of “progeroid” syndromes which are not progeria may have diseases that are passed down in families. However, progeria is a new change in that family, and dominant because only one copy of the gene needs to be changed in order to have the syndrome.

For parents who have never had a child with progeria, the chance of having a child with progeria is 1 in 20 million. But for parents who have already had a child with progeria, the chance of having a child with progeria is much higher – about 2-3%. Why the increase? This is due to a condition called “mosaicism”, where a parent has the genetic mutation for progeria in a small proportion of their cells, but does not have progeria. Prenatal testing is available to look for the genetic change that causes progeria.

 

Keywords: progeria inherited; progeria inheritance.

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