Intestine Determines Cancer Resistance

A recent study in Nature found that if you can maintain the intestinal health of mice receiving a lethal dose of chemotherapy, you can ensure that they have enough energy and nutrition to maintain life, significantly improving the survival rate of advanced cancer.

Our gut is the hardworking scavenger in our body. It works tirelessly every day and absorbs nutrients to remove toxins. However, do you know? The intestine is also a loyal fan of the body. The healthy intestine operation can provide us with more energy and more nutrients to fight off the detestable cancer cells.

Cancer treatment is like using a fire hydrant to water indoor plants. Sometimes too much water can cause plants to die. Just as too many chemotherapy and radiation treatments kill or hurt normal tissues and organs before they kill tumor cells. However, a new study found that even if the dose of radiotherapy and chemotherapy is increased, the survival rate of patients can be significantly improved if the intestinal health of patients with advanced cancer can be maintained. This is the result of an innovative cancer treatment research recently published by Nature magazine: a new biological mechanism for maintaining the gastrointestinal health of lethal dose chemotherapy mice.

In our gastrointestinal tract, there is a group of lovely “repair workers” who are waiting to repair the injured intestinal tissues. They are “intestinal stem cells.” However, when the body of patients with advanced metastatic cancer suffers from large doses or even lethal doses of chemotherapy, the melee strength of the repairman is difficult to repair the damaged intestinal tissue. Due to the severe damage to the intestines, the patients could not maintain sufficient energy intake and could not complete other important life activities.

The new biological mechanism has solved this problem. Scientists combine the two protein molecules of R-spondin1 and SLIT2 with certain special molecules on the mouse intestinal stem cells to strengthen the strength of the intestinal “repair workers” and greatly improve the “repair workers”. The ability to repair, even if the mice received a lethal dose of chemotherapy, can still maintain a healthy intestine, thus greatly improving the survival rate of mice.

The task of the scientists was to try to increase the survival rate of mice receiving this particular molecule to 100%.

Leave a Reply