Insulin-like Growth Factor – 1- Reference Range

Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein that in humans is encoded by the IGF1 gene. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults.

The reference range of IGF-1 blood levels are as follows:

  • Adults: 200 to 450 ng/ml (nanograms per milliliter).
  • One-third of individuals over 50 years of age: less than 200 ng/ml
  • Youth: over 600- 800 ng/ml.

Decreased IGF-1 levels may indicate:

  • Pituitary function (hypopituitarism)
  • Pituitary damage following conditions such as trauma, infections, and inflammation.
  • Nutritional deficiencies such as anorexia nervosa
  • Chronic kidney disease
  • Liver disease

Increased IGF-1 levels may indicate:

  • Pregnancy
  • Pituitary tumors (usually benign)
  • Recurrence of the pituitary tumor

Keywords: Insulin-like Growth Factor – 1

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