Hypertonic Saline: Uses & Side Effects


Sodium Chloride Injection is an electrolyte and fluid replenisher used as a source of water and electrolytes. Hypertonic saline 3% and 5% sodium chloride is available in generic form.

Dosage of Hypertonic Saline is dependent upon the age, weight, and clinical condition of the patient as well as laboratory determinations. Other drugs may affect Hypertonic Saline. Tell your doctor about all the prescription and over-the-counter medications and supplements you use. Hypertonic Saline should be given to a pregnant woman only if prescribed. Consult your doctor before breastfeeding.

Side Effects

Common side effects of hypertonic saline 3% and 5% sodium chloride include:

  • fever,
  • infection at injection site, or
  • redness/red streaking and swelling from the site of injection.

Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia.

If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures, and save the remainder of the fluid for examination if deemed necessary.

Keywords: hypertonic saline.

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