Huntington’s disease is an inherited disease of the nervous system. It gradually destroys the nerve cells of the brain. There is no cure for
the nerve damage resulting from Huntington’s disease; it will last forever.
Huntington’s disease impacts a person’s functional and mental abilities, and usually results in movement, cognitive and psychiatric disorders. However, treatments available now can’t prevent the decline of the body functions.
Huntington’s disease is a rare disorder. Based on Huntington’s disease statistics, it is estimated that it affects about 30,000 people in the United States alone.
disease is caused by an inherited defect in a single gene. A person with one
parent who has an abnormal copy of the gene, has a 50 percent chance of
inheriting the gene and developing the disease.
The genetic mutation responsible for Huntington’s disease is different from many other mutations. An area within the gene is copied too many times. The number of repeated copies tends to increase with each generation.
There are two types of
Huntington’s disease: adult onset and early onset.
adult onset usually begin when people are in their 30s or 40s.
Initial symptoms include:
- minor involuntary movements
- poor coordination and balance
- difficulty understanding new
- trouble making decisions
come out later include:
- involuntary twitching movements,
- difficulty walking
- trouble swallowing and speaking
- memory loss
- personality changes
- speech changes
- decline in cognitive abilities
- Muscle problems, such as rigidity
or muscle contracture (dystonia)
- Slow or abnormal eye movements
Symptoms of early onset one usually start to appear in childhood or adolescence. Early-onset Huntington’s disease causes mental, emotional, and physical changes, such as:
- slurred speech
- slow movement
- frequent falling
- contracted and rigid muscles
- contracted and rigid muscles
- tremors or slight involuntary movements
- sudden decline in school performance
- Loss of previously learned academic or physical skills
There are several steps to diagnose a Huntington’s disease:
neurologist will ask you questions and conduct relatively simple tests to check
your corresponding motor, sensory and psychiatric symptoms.
Psychiatric tests check your coping skills, judging abilities,
emotional state, and behavioral patterns, signs of disordered thinking and evidence
of substance abuse.
- Brain imaging
The imaging technologies may include electroencephalogram (EEG) tests, magnetic resonance imaging (MRI) scans and computed tomography (CT) scans.
Genetic tests may also help you decide whether or not to have children.
Medications can lessen
some of your physical and psychiatric symptoms.
- Tetrabenazine (Xenazine), haloperidol (Haldol) and levetiracetam(Keppra) are examples of useful medications to treat movement disorders.
- Antidepressants, antipsychotic drugs and mood-stabilizing drugs can help to treat psychiatric disorders.
It can help improve your coordination, balance, and flexibility.
- Occupational therapy
It can be used to evaluate your
daily activities and help you to practice body movements, eat and drink, bath
and get dressed with devices.
It may be
able to help you speak clearly and deal with swallowing and eating problems.
It can help you work through emotional and mental problems and develop your coping skills.
Keywords: Huntington’s disease.