How to Cure Gastroparesis?

Any medications suggested for gastroparesis?

Speaking of the medications that can be used to help reduce symptoms of gastroparesis, prokinetic agents and antiemetic agents are the commonly used drugs for it.

Metoclopramide is the only one drug approved by the U.S. Food and Drug Adiministration (FDA) for the treatments of gastroparesis.

Based on clinical experiences, doctors may also prescribe other off-label drugs, which include:

Prokinetic Agents:

  • Metoclopramide: Tardive dyskinesia is the most bothersome side effect of it, 20–40% of patients cannot take this drug.
  • Domperidone: It has never been approved by the FDA, older patients and those with known cardiac disease should pay more attention when taking it.
  • Erythromycin: About 40% of people with diabetic gastroparesis will improve with short courses of erythromycin, but its effectiveness often decrease sharply after several weeks of taking this drug.

Antiemetic Agents:

  • Serotonin 5-HT3 receptor antagonists
  • Antihistamines
  • Phenothiazines
  • Low-dose tricyclic antidepressants

All these antiemetic agents can be taken as an oral tablet, dissolvable tablet, liquid, or intravenously as required.

Botulinum Toxin Injection: It is a nerve blocking agent. studies showed that with the injections of Botox into the pylorus, modest improvements have been achieved in gastroparesis symptoms and the rate of gastric emptying.

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