Previous studies have shown that people carrying HIV virus may have several types of cancer, particularly the viral-related cancers such as cervical and anal cancers(caused by human papillomaviruses, HPV), liver cancer(caused by hepatitis B and hepatitis C) and certain types of Lymphoma (associated with eb virus). But for other types of cancers, there appears to be no difference between HIV-positive and HIV-negative people.
To date, there has been limited research on disease progression and prognosis in HIV-positive patients. Some studies have shown that people living with HIV are later diagnosed with cancer, are less likely to be treated, and have lower survival rates, but the data has been inconsistent, and they believe this is the background. Greater immunosuppression may result in more severe cancers and may reduce the tolerability of cancer treatment. People who are HIV positive are also more likely to have risk factors such as smoking and co-infection of the virus, thereby affecting the risk and outcome of cancer.
In the Johns Hopkins cohort, 69% were male, 78% were black, and the median age was 50. The most common cancers are non-Hodgkin’s lymphoma (21%), lung cancer (17%), liver cancer (9%), Hodgkin’s lymphoma (7%), prostate cancer (7%), breast cancer (6% ) and anal cancer (6%).
Based on age, sex, race/ethnicity, year of diagnosis, and type of cancer, the Johns Hopkins population is more likely to be diagnosed with local cancer than people in the SEER database (30% vs 6%, with a 24% probability difference) %). Local cancer usually indicates that it is in an early stage, although some cancers progress slowly and can still be localized after they develop.