Frank’s sign is a diagonal crease in the ear lobe extending from the tragus across the lobule to the rear edge of the auricle.
Frank’s sign may indicate cardiovascular disease or diabetes but not linked to the severity of the condition. Some studies have described Frank’s sign as a marker of cardiovascular disease but not linked to the severity of the condition. But other studies rebutted any association between Frank’s sign and coronary artery disease in diabetics.
Therefore, further studies are needed to verify the association between Frank’s sign and cardiovascular disease including stroke and heart disease.