Fondaparinux: Uses, Side Effects

Fondaparinux blocks the activity of certain
clotting substances in the blood.

Fondaparinux is used to prevent a type of
blood clot called deep vein thrombosis (DVT), which can lead to blood clots in
the lungs (pulmonary embolism). A DVT can occur after certain types of surgery.

Fondaparinux is also used together with
warfarin (Coumadin, Jantoven) to treat DVT, including pulmonary embolism.

Fondaparinux may also be used for purposes
not listed in this medication guide.

Before taking this medicine

You should not use this medicine if you
have ever had a severe allergic reaction to fondaparinux, or if you have:

  • active or uncontrolled bleeding;
  • severe kidney disease;
  • an infection in the lining of your heart (also called bacterial
    endocarditis); or
  • a low level of platelets in your blood after testing positive for a
    certain antibody while using fondaparinux.

You should not use fondaparinux to prevent
blood clots after surgery if you weigh less than 110 pounds (50 kilograms).

Tell your doctor if you have ever had:

  • a bleeding disorder that is inherited or caused by disease;
  • a stroke;
  • eye problems caused by diabetes;
  • uncontrolled high blood pressure;
  • stomach or intestinal bleeding or ulcer;
  • brain, spine, or eye surgery;
  • an allergy to latex; or
  • liver or kidney disease.

Using fondaparinux during pregnancy may
cause bleeding in the mother or the unborn baby. Tell your doctor if you are
pregnant or if you become pregnant.

It may not be safe to breast-feed while using
this medicine. Ask your doctor about any risk.

Side effects

Get emergency medical help if you have
signs of an allergic reaction: hives; difficult breathing; swelling of your
face, lips, tongue, or throat.

Also seek emergency medical attention if
you have symptoms of a spinal blood clot: back pain, numbness or muscle
weakness in your lower body, or loss of bladder or bowel control.

Fondaparinux can cause you to bleed more
easily. Call your doctor at once if you have signs of bleeding such as:

  • easy bruising or bleeding (nosebleeds, bleeding gums, heavy
    menstrual bleeding);
  • pain, swelling, or drainage from a wound or where a needle was
    injected in your skin;
  • bleeding from wounds or needle injections, any bleeding that will
    not stop;
  • headaches, dizziness, weakness, feeling like you might pass out;
  • urine that looks red, pink, or brown; or
  • bloody or tarry stools, coughing up blood or vomit that looks like
    coffee grounds.

Also call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • low potassium level–leg cramps, constipation, irregular heartbeats,
    fluttering in your chest, increased thirst or urination, numbness or tingling,
    muscle weakness or limp feeling;
  • low red blood cells (anemia)–pale skin, unusual tiredness, feeling
    light-headed or short of breath, cold hands and feet;
  • low potassium–leg cramps, constipation, irregular heartbeats,
    fluttering in your chest, increased thirst or urination, numbness or tingling,
    muscle weakness or limp feeling;
  • low red blood cells (anemia)–pale skin, feeling light-headed or
    short of breath, rapid heart rate, trouble concentrating; or

Common side effects may include:

  • bleeding, bruising;
  • sleep problems (insomnia);
  • rash, blisters;
  • dizziness, confusion; or
  • minor bleeding, rash, itching, or oozing where the medicine was
    injected.

This is not a complete list of side effects
and others may occur. Call your doctor for medical advice about side effects.

What other drugs will affect fondaparinux?

Tell your doctor about all your other medicines,
especially:

  • any other medications to treat or prevent blood clots;
  • a blood thinner–heparin warfarin (Coumadin, Jantoven); or
  • NSAIDs (nonsteroidal anti-inflammatory drugs) –aspirin, ibuprofen
    (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin,
    meloxicam, and others.

This list is not complete, and many other drugs may affect fondaparinux. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Keyword: fondaparinux.

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