Fluorouracil (Systemic): Uses & Sides Effects

is used to treat colorectal cancer, breast cancer,
stomach cancer, pancreatic cancer.

is this medicine (Fluorouracil) best taken?

Use fluorouracil (systemic) as ordered by
your doctor. Read all information given to you. Follow all instructions

  • It is given as an infusion into a vein over a period of time.
  • It may be given as a shot into a vein.

do I need to tell my doctor BEFORE I take Fluorouracil?

If you have an allergy to fluorouracil or
any other part of fluorouracil (systemic).

If you are allergic to any drugs like this
one, any other drugs, foods, or other substances. Tell your doctor about the
allergy and what signs you had, like rash; hives; itching; shortness of breath;
wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

If you have any of these health problems: An
infection, low blood cell counts, or poor diet.

If you are breast-feeding. Do not
breast-feed while you take fluorouracil (systemic).

This is not a list of all drugs or health
problems that interact with fluorouracil (systemic).

Tell your doctor and pharmacist about all
of your drugs (prescription or OTC, natural products, vitamins) and health
problems. You must check to make sure that it is safe for you to take
fluorouracil (systemic) with all of your drugs and health problems. Do not
start, stop, or change the dose of any drug without checking with your doctor.

are some things I need to know or do while I take Fluorouracil?

Tell all of your health care providers that
you take fluorouracil (systemic). This includes your doctors, nurses,
pharmacists, and dentists.

You may have more chance of getting an
infection. Wash hands often. Stay away from people with infections, colds, or

You may bleed more easily. Be careful and
avoid injury. Use a soft toothbrush and an electric razor.

If you have upset stomach, throwing up,
diarrhea, or are not hungry, talk with your doctor. There may be ways to lower
these side effects.

If diarrhea or throwing up happens, talk
with the doctor. You will need to make sure to avoid dehydration and
electrolyte problems.

Have blood work checked as you have been
told by the doctor. Talk with the doctor.

The chance of severe and sometimes deadly
side effects is raised in patients who do not have the enzyme dihydropyrimidine
dehydrogenase (DPD) in the body. These include mouth irritation or sores,
diarrhea, low white blood cell counts, or nerve problems.

This medicine may cause heart problems like
heart attack, heart failure, and an abnormal heartbeat. These effects may be
more common in people who have had heart disease before. Talk with the doctor.

If you are taking warfarin, talk with your
doctor. You may need to have your blood work checked more closely while you are
taking it with fluorouracil (systemic).

Talk with your doctor before getting any
vaccines. Use of some vaccines with fluorouracil (systemic) may either raise
the chance of an infection or make the vaccine not work as well.

You may get sunburned more easily. Avoid
sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear
that protects you from the sun.

This medicine may affect fertility.
Fertility problems may lead to not being able to get pregnant or father a
child. Talk with the doctor.

If you are a man and have sex with a female
who could get pregnant, protect her from pregnancy during care and for 3 months
after care ends. Use birth control that you can trust.

If you are a man and your sex partner gets
pregnant while you take fluorouracil (systemic) or within 3 months after your
last dose, call your doctor right away.

This medicine may cause harm to the unborn
baby if you take it while you are pregnant.

Use birth control that you can trust to
prevent pregnancy while taking fluorouracil (systemic) and for 3 months after
care ends.

If you get pregnant while taking
fluorouracil (systemic) or within 3 months after your last dose, call your
doctor right away.


All drugs may cause side effects. However,
many people have no side effects or only have minor side effects. Call your
doctor or get medical help if any of these side effects or any other side
effects bother you or do not go away:

  • Upset stomach or throwing up.
  • Not hungry.
  • Diarrhea.
  • Mouth irritation or mouth sores.
  • Hair loss.
  • Dry skin.
  • Change in nails.

Always consult your healthcare provider to
ensure the information displayed on this page applies to your personal

Keywords: fluorouracil.

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