Estradiol (E2)

Reference range of Estradiol (E2) is:

  • Men: 50 ~ 200pmol/L
  • Female: follicular phase: 94 ~ 433pmol/L; luteal stage: 499 ~ 1580pmol/L; ovulation period: 704 ~ 2200pmol/L; menopause: 40 ~ 100pmol/L.

Increased levels of estradiol (E2) or estrone (E1) are seen in:

  • Girls and Women:
    Early (precocious) puberty
    Tumors of the ovary or adrenal glands
  • Boys and Men:
    Enlarged breasts (gynecomastia)
    Tumors of the testicles (testicular cancer) or adrenal glands
    Delayed puberty
    Both Women and Men:
    Hyperthyroidism
    Cirrhosis

In women, decreased levels of estrogen are seen in:

  • Turner syndrome, an inherited condition in women caused by a missing or abnormal X chromosome and characterized by underdeveloped female sex characteristics.
  • Low level of pituitary hormones (hypopituitarism).
  • Dysfunction of the ovaries (female hypogonadism).
  • Failing pregnancy (estriol) .
  • Eating disorders such as anorexia nervosa.
  • After menopause (estradiol) .
  • PCOS (Polycystic ovarian syndrome, Stein-Leventhal syndrome) .
  • Extreme endurance exercise.

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