GFR (glomerular filtration rate) is equal to the total of the filtration rates of the functioning nephrons in the kidney, it is usually accepted as the best overall index of kidney function.

eGFR means the estimated GFR, because GFR can’t be measured directly, it is calculated based on two formulas. The calculation of GFR is based on a person’s serum creatinine level and some variables including gender, age, weight and race.

**Modification in calculating African American GFR**

The CKD-EPI equation and the MDRD Study equation are the two formulas to estimate GFR. Both are considered accurate.

In the calculation of GFR of African Americans’, the formula is to multiply the GFR estimate for Caucasians by 1.16 for the CKD-EPI equation and 1.21 for the MDRD Study equation.

MDRD equation：

*GFR = 186 x (Stand. SCr)-1.154x (age)-0.203x (0.742 if female) x (1.210 if African American)*

Assume an American white and an African American have the same serum creatinine level, are at the same age and weight, if the American white gets a GFR value 65 mL/min/1.73㎡, the African American gets a GFR value 78.65 mL/min/1.73㎡.

In a word, there’s a modification for African American in the calculation of GFR.

The modification is based on that fact that African Americans have, on average, greater muscle mass and thus higher serum creatinine levels.

**African American refers to the same reference chart**

When the GFR is calculated, both Caucasians and African Americans refer to the same reference table. The modification occurs only in the calculation.

Kidney damage:

Stage 1 – normal or minimal kidney damage with normal GFR, eGFR 90+

Stage 2 – mild decrease in GFR, eGFR 60-89

Stage 3 – moderate decrease in GFR, eGFR 30-59

Stage 4 – severe decrease in GFR, eGFR 15-29

Stage 5 – kidney failure, eGFR <15

keywords: eGFR non African American, estimated GFR non African American, extended gfr non african american, eGFR N-AP POC, eGFR non-AA, GFR non-AA