Duloxetine: Uses, Side Effects

Duloxetine is a selective serotonin and
norepinephrine reuptake inhibitor antidepressant (SSNRI). Duloxetine affects
chemicals in the brain that may be unbalanced in people with depression.

Duloxetine is used to treat major
depressive disorder in adults. It is also used to treat general anxiety
disorder in adults and children who are at least 7 years old.

Duloxetine is also used in adults to treat
fibromyalgia (a chronic pain disorder), or chronic muscle or joint pain (such
as low back pain and osteoarthritis pain).

Duloxetine is also used to treat pain
caused by nerve damage in adults with diabetes (diabetic neuropathy).

Important Information

Do not take duloxetine within 5 days before
or 14 days after you have used an MAO inhibitor, such as isocarboxazid,
linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or
tranylcypromine. A dangerous drug interaction could occur.

Some young people have thoughts about
suicide when first taking an antidepressant. Stay alert to changes in your mood
or symptoms. Report any new or worsening symptoms to your doctor.

Do not stop using duloxetine without first
talking to your doctor.

Before taking this medicine

You should not use duloxetine if you are
allergic to it.

Be sure your doctor knows if you also take
stimulant medicine, opioid medicine, herbal products, or medicine for
depression, mental illness, Parkinson’s disease, migraine headaches, serious
infections, or prevention of nausea and vomiting. These medicines may interact
with duloxetine and cause a serious condition called serotonin syndrome.

Duloxetine is not approved for use by
anyone younger than 7 years old.

Tell your doctor if you have ever had:

  • liver or kidney disease
  • slow digestion
  • a seizure

  • bleeding problems
  • narrow-angle glaucoma
  • bipolar disorder (manic depression)
  • drug addiction or suicidal thoughts

Some young people have thoughts about
suicide when first taking an antidepressant. Your doctor should check your
progress at regular visits. Your family or other caregivers should also be
alert to changes in your mood or symptoms.

Taking duloxetine during pregnancy may
cause breathing problems, feeding problems, seizures, or other complications in
the newborn baby. However, you may have a relapse of depression if you stop
taking this medicine. Tell your doctor right away if you become pregnant. Do
not start or stop taking this medicine without your doctor’s advice.

If you are pregnant, your name may be
listed on a pregnancy registry to track the effects of duloxetine on the baby.

It may not be safe to breast-feed while
using this medicine. Ask your doctor about any risk.

Side effects

Get emergency medical help if you have
signs of an allergic reaction to duloxetine (hives, difficult breathing,
swelling in your face or throat) or a severe skin reaction (fever, sore throat,
burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Report any new or worsening symptoms to
your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble
sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive,
restless, hyperactive (mentally or physically), more depressed, or have
thoughts about suicide or hurting yourself.

To make sure this medicine is safe for you,
tell your doctor if you have ever had:

  • pounding heartbeats or fluttering in your chest
  • a light-headed feeling, like you might pass out
  • easy bruising, unusual bleeding
  • vision changes
  • painful or difficult urination
  • impotence, sexual problems
  • liver problems – right-sided upper stomach pain, itching, dark
    urine, jaundice (yellowing of the skin or eyes)
  • low levels of sodium in the body – headache, confusion, slurred
    speech, severe weakness, vomiting, loss of coordination, feeling unsteady
  • a manic episode – racing thoughts, increased energy, reckless
    behavior, feeling extremely happy or irritable, talking more than usual, severe
    problems with sleep.

Seek medical attention right away if you
have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever,
sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of
coordination, nausea, vomiting, or diarrhea.

Common duloxetine side effects may include:

  • drowsiness
  • nausea, constipation, loss of appetite
  • dry mouth
  • increased sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Keyword: duloxetine.

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