Cyclobenzaprine: Uses, Side Effects

Cyclobenzaprine is a muscle relaxant. It
works by blocking nerve impulses (or pain sensations) that are sent to your

Cyclobenzaprine is used together with rest
and physical therapy to treat skeletal muscle conditions such as pain or

Cyclobenzaprine may also be used for
purposes not listed in this medication guide.

Important Information

You should not use cyclobenzaprine if you
have an allergy to the medication, a certain type of thyroid disorder
(hyperthyroidism), heart block, congestive heart failure, a heart rhythm
disorder, or you have recently had a heart attack.

Do not use cyclobenzaprine if you have
taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid,
phenelzine, rasagiline, selegiline, or tranylcypromine.

Before taking this medicine

You should not use cyclobenzaprine if you
are allergic to it, or if you have:

  • Hyperthyroidism
  • heart block, heart rhythm disorder, congestive heart failure

if you have recently had a heart attack,
you should be careful of taking this medication.

Cyclobenzaprine is not approved for use by
anyone younger than 15 years old.

Do not use cyclobenzaprine if you have
taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could
occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline,
selegiline, and tranylcypromine.

Some medicines can interact with
cyclobenzaprine and cause a serious condition called serotonin syndrome. Be
sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal
products, or medicine for depression, mental illness, Parkinson’s disease,
migraine headaches, serious infections, or prevention of nausea and vomiting.
Ask your doctor before making any changes in how or when you take your

To make sure cyclobenzaprine is safe for
you, tell your doctor if you have:

  • thyroid disease
  • liver disease
  • glaucoma
  • enlarged prostate
  • problems with urination

It is not known whether cyclobenzaprine
will harm an unborn baby. Tell your doctor if you are pregnant or plan to
become pregnant.

It may not be safe to breast-feed while
using this medicine. Ask your doctor about any risk.

Older adults may be more sensitive to the
effects of this medicine.

Side effects

Get emergency medical help if you have
signs of an allergic reaction to cyclobenzaprine: hives; difficult breathing;
swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your
doctor at once if you have:

  • fast or irregular heartbeats
  • chest pain or pressure, pain spreading to your jaw or shoulder
  • sudden numbness or weakness (especially on one side of the body),
    slurred speech, balance problems

Seek medical attention right away if you
have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever,
sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of
coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in
older adults.

Common cyclobenzaprine side effects may

  • drowsiness, tiredness
  • headache, dizziness
  • dry mouth
  • upset stomach, nausea, constipation

What other drugs will affect

Using cyclobenzaprine with other drugs that
make you drowsy can worsen this effect. Ask your doctor before using opioid
medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or

Tell your doctor about all your other
medicines, especially:

  • MAO inhibitors, such as isocarboxazid, linezolid, phenelzine,
    rasagiline, selegiline, or tranylcypromine
  • Any antidepressant or anxiety medications
  • bupropion (Zyban, for smoking cessation or Wellbutrin, for
  • meperidine
  • tramadol
  • verapamil
  • cold or allergy medicine that contains an antihistamine (Benadryl
    and others)
  • medicine to treat Parkinson’s disease
  • medicine to treat excess stomach acid, stomach ulcer, motion
    sickness, or irritable bowel syndrome
  • medicine to treat overactive bladder
  • bronchodilator asthma medication

This list is not complete. Other drugs may interact with cyclobenzaprine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Keyowrd: cyclobenzaprine.

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