Colchicine and Probenecid: Uses, Side Effects

Colchicine alters the way your body responds to uric acid crystals. Too much uric acid in the body is what leads to the symptoms of gout (swelling and pain).

Probenecid reduces the amount of uric acid in your body by causing it to be passed in your urine.

Colchicine and probenecid is a combination medicine used to prevent gout attacks. This medication will not cure gout and it will not stop a gout attack that has already started.


What should you know before taking this medicine?

This medication will not stop a gout attack that has already started. Your doctor may prescribe other medications to treat your gout. Take all of your gout medications as directed.

To make sure colchicine and probenecid is safe for you, tell your doctor if you have:

  • heart disease;
  • kidney disease or a history of kidney stones;
  • liver disease;
  • a blood disease;
  • stomach problems such as an ulcer or severe intestinal disorder;
  • if you drink large amounts of alcohol; or
  • if you are receiving chemotherapy or radiation.

It is not known whether colchicine and probenecid will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is also not known whether colchicine and probenecid passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

In addition, older adults may be more sensitive to the side effects of this medication.


Side effects

Common side effects may include:

  • mild nausea or stomach pain, loss of appetite;
  • headache;
  • dizziness;
  • hair loss; or
  • flushing (warmth, redness, or tingly feeling).

Stop using colchicine and probenecid and call your doctor at once if you have:

  • painful urination, severe pain in your side or lower back, blood in your urine, little or no urinating;
  • fever, severe muscle weakness, mood changes, seizure (convulsions);
  • easy bruising or bleeding, unusual weakness; or
  • severe diarrhea, nausea, vomiting, or stomach pain.


What other drugs will affect colchicine and probenecid?

Other drugs may interact with colchicine and probenecid, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.


Keyword: colchicine and probenecid

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