Clinical Trial – Comparison of Optimal Hypertension Regimens (AIMHY-INFORM) – Hypertension

High blood pressure (Hypertension) is extremely common and is a major cause of heart disease, kidney disease and stroke. One in three of the UK (United Kingdom) population will require treatment for hypertension at some point in their lives. A healthy lifestyle alone is often not enough to control blood pressure, and drug treatment is usually required. Although a wide variety of drugs are available to treat hypertension, choosing the right kind of tablet or combination of tablets for individual patients is a problem, and therefore many people have poor blood pressure control.

Hypertension treatment within the UK is currently selected according to age and self-defined ethnicity (SDE). There are limitations to this approach which include wide variability in the response to hypertension drug classes between people. There is also uncertainty about selecting hypertension drugs for ethnic minorities other than those of African/Caribbean ancestry, for example, South Asians because of a lack of information from trials. In the AIM HY-INFORM study the investigators are looking to recruit equal number of black/caribbean, south asian and white european participants to be able to compare differences in hypertension treatments and ethnicity.

The primary objective of this study is to determine if the response to antihypertensive drugs differs by self defined ethnicity.

 

Study Type  : Interventional  (Clinical Trial)
Estimated Enrollment  : 1320 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Comparison of Optimal Hypertension Regimens (Part of the Ancestry Informative Markers in Hypertension (AIMHY) Programme – AIMHY-INFORM)
Study Start Date  : November 2016
Estimated Primary Completion Date  : November 2020
Estimated Study Completion Date  : November 2021

 

Contacts
Contact: Gemma Bocking 01223 596377 gemma.bocking@addenbrookes.nhs.uk
Contact: Alicia Gore 01223 256599 alicia.gore@addenbrookes.nhs.uk

 

Locations
United Kingdom
Cambridge University Hospitals NHS Foundation Trust Recruiting
Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ
Contact: Gemma Bocking    01223 596377    gemma.bocking@addenbrookes.nhs.uk
Contact: Alicia Gore    01223 256599    alicia.gore@addenbrookes.nhs.uk
Principal Investigator: Joseph Cheriyan
Queen Elizabeth Hospital Recruiting
Birmingham, United Kingdom, B15 2TH
Principal Investigator: Una Martin
Sandwell & West Birmingham Hospitals NHS Trust Recruiting
Birmingham, United Kingdom, B18 7QH
Contact: Ronnie HAYNES    0121 507 5113    ronnie.haynes@nhs.net
Contact: Rebecca Brown    0121 507 6657    Rebecca.brown15@nhs.net
Principal Investigator: Gregory Lip
University Hospital Llandough Recruiting
Cardiff, United Kingdom, CF64 2XX
Contact: Maggie Munnery    029 20416278    MMunnery@cardiffmet.ac.uk
Contact: Barry McDonnell    029 206827    bmcdonnell@cardiffmet.ac.uk
Principal Investigator: James Coulson
University of Glasgow Recruiting
Glasgow, United Kingdom, G12 8TA
Principal Investigator: Sandosh Padmanabhan
Leicester General Hospital Not yet recruiting
Leicester, United Kingdom, LE5 4PW
Principal Investigator: Kamlesh Khunti
William Harvey Research Institute, Barts and the London Medical School Recruiting
London, United Kingdom, EC1M 6BQ
Principal Investigator: David Collier
St. Thomas Hospital Recruiting
London, United Kingdom, SE1 7EH
Principal Investigator: Phil Chowienczyk
Sub-Investigator: Luca Faconti
Imperial College Healthcare NHS Trust St. Marys Hospital Not yet recruiting
London, United Kingdom, W2 1NY
Principal Investigator: Simon Thom
University College London Not yet recruiting
London, United Kingdom, WC1E 7HB
Principal Investigator: Alun Hughes
Manchester Royal Infirmary Recruiting
Manchester, United Kingdom, M13 9WL
Principal Investigator: Tony Heagerty
Newcastle Hospital NHS Foundation Trust Not yet recruiting
Newcastle, United Kingdom, NE2 4HH
Principal Investigator: Simon Thomas

 

ClinicalTrials.gov Identifier: NCT02847338

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