A high amount or titer of anti-LKM-1 indicates that it is likely that the person tested has type 2 autoimmune hepatitis, but the result is not definitive.
A liver biopsy may be performed to evaluate liver tissue for damage and scarring to help confirm the diagnosis.
If the anti-LKM-1 test is negative, but SMA and/or ANA are positive, then the person likely has type 1 autoimmune hepatitis.
If both are negative, then the person’s symptoms are likely due to a cause other than autoimmune hepatitis.
However, the condition is not entirely ruled out. Not all people with autoimmune hepatitis will produce anti-LKM-1 or SMA antibodies; some people produce other autoantibodies that are rarely tested.
Keywords: Anti-Liver/Kidney Microsomal Antibodies Type1; Anti-LKM-1; Anti-LKM1; Anti-P450 2D6 Antibody; Liver Kidney Microsomal Type 1 Antibodies; Liver Kidney Microsome Type 1 Antibodies (Cytochrome P450 2D6 Antibodies); LKM1 Antibodies